Lab News

April 2018 Kyle Roux was invited to discuss his research program as part of a seminar series hosted by the University of Minnesota Department of Genetics, Cell Biology and Development.  He presented on "Tracking protein footprints with BioID".

March 2018 Kyle Roux published a research manuscript in Current Protocols in Protein Science detailing the technical protocol developed for BioID. BioID is a unique method to screen for protein interactions in a variety of cell types. “BioID: a screen for protein-protein interactions”

February 2018 Dr. Kyle Roux's lab presented their research on the nuclear envelope an innate immunity at the annual meeting of the American Society for Cell Biology and European Molecular Biology Organization (ASCB-EMBO) in Philadelphia, PA.

November 2017 USD Basic Biomedical Sciences graduate student Birendra KC successfully defended his thesis dissertation performed in the Roux lab. His dissertation was titled “Application of BioID to identify novel nuclear envelope constituents and functions."

October 2017 Dr. Kyle Roux gave an invited seminar on his research program titled "Tracking protein footprints with BioID" to physicians and scientists at the Mayo Clinic in Rochester, MN.

October 2017 Dr. Kyle Roux gave an invited seminar on his research program to the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado-Boulder. "Tracking protein footprints with BioID."

July 2017 Dr. Kyle Roux served on a study section panel for the National Institutes of Health Common Fund's 4D Nucleome (4DN) program. This study section reviewed Transformative Collaborative Project Award (TCPA) applications.

June 2017 Dr. Kyle Roux published a research article in Molecular Biology of the Cell using his BioID technology to identify novel molecular constituents of the inner nuclear membrane. "VRK2A is an A-type-lamin-dependent nuclear envelope kinase that phosphorylates BAF."

April 2017 Kyle Roux, PhD, was awarded a research grant from BioSNTR for his project, "In Planta BioID to detect protein-protein interactions in plant cells."

April 2017 A team of Sanford physicians and scientists led by Drs. Megan Landsverk, Kyle Roux, and Jill Weimer published a research article in American Journal of Medical Genetics that investigated the molecular consequences of PHOX2B mutations in patients with congenital central hypoventilation syndrome. "Nonsense pathogenic variants in exon 1 of PHOX2B lead to translational reinitiation in congenital central hypoventilation syndrome."

December 2016 Dr. Kyle Roux and Birenda KC published "The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity" in Scientific Reports. The study describes how mechanical connections that connect the nucleus to the cell impact the cell's ability to regulate gene expression in response to mechanical stimuli from the cell's exterior. https://www.ncbi.nlm.nih.gov/pubmed/?term=The+mammalian+LINC+complex+regulates+genome+transcriptional+responses+to+substrate+rigidity

Decemeber 2016 Dr. Kyle Roux and Birenda KC, USD Graduate Student, attended the annual meeting of the American Society for Cell Biology in San Francisco, CA. They presented their work on a novel lamin-associated kinase in a session titled Nuclear Lamins and Laminopathies.

October 2016, Dr. Roux received the Blue Flame Award from Addgene, a nonprofit plasmid repository, for receiving over 3,700 requests his BioID plasmids from researchers around the world.

October 2016, Dr. Roux gave an invited seminar entitled “Tracking protein footprints with BioID” to the Department of Biochemistry at the University of Mississippi Medical Center in Jackson, MS.

September 2016, Dr. Roux published an invited review entitled "Filling the void: Proximity-based labeling of proteins in living cells" for the 25th anniversary edition of Trends in Cell Biology that highlights the technological innovations that will enable the future of cell biology research. https://www.ncbi.nlm.nih.gov/pubmed/?term=27667171

August 2016, Drs. Roux was awarded a Sanford-Mayo Collaborative Research Grant for the 2016-2017 year. He will be working in partnership with Dr. Paul Galardy at the Mayo Clinic to study the mechanisms by which a regulator of epigenetics and DNA repair affects the progression of neuroblastoma, a common and highly aggressive tumor affecting children.

July 2016, Dr. Kyle Roux and members of his team, Dr. Daein Kim and Sam Jenson, recently published a book chapter that explores novel methods for investigating protein interactions in a cellular organelle known as the nuclear envelope which is a critical cellular structure in a myriad of cellular processes. The chapter, entitled “Identifying Protein-Protein Associations at the Nuclear Envelope with BioID” was published in the 2016 edition of Methods in Molecular Biology.

May 2016, Dr. Kyle Roux was recently invited to the University of Alberta to meet with faculty and discuss his ongoing research and technology development. The title of Dr. Roux’s invited lecture was: “Tracking protein footprints with BioID.”

April 2016, A research publication from the Roux Lab was recently recommended for Faculty of 1000 as being of special significance in its field. F1000Prime publishes recommendations of articles in biology and medicine from a faculty of around 10,000 scientists and clinical researchers aimed at highlighting highly significant research. The article entitled “An improved smaller biotin ligase for BioID proximity labeling” was recently published in the journal Molecular Biology of the Cell.

March 2016, The lab of Dr. Kyle Roux recently published a study entitled ” An improved smaller biotin ligase for BioID proximity labeling” in the journal Molecular Biology of the Cell. This study introduces improvements to BioID, a method invited by Dr. Roux that uses a promiscuous biotin ligase to detect protein-protein interactions in living cells.

January 2016, Dr. Kyle Roux and members of his lab recently co-authored a book chapter in Methods in Enzymology entitled “BioID Identification of Lamin-Associated Proteins.” This chapter discusses the use of BioID, a research technique developed by Dr. Roux, to elucidate novel lamin-interacting proteins and its applications in a broad range of biological systems, and provides detailed protocols to guide this new and innovative applications.