Lab News

June 2018 Kamesh Surendran recently reviewed scientific abstracts submitted in the Development, Stem Cells and Regenerative Medicine category for Kidney Week 2018. Kidney Week is an annual scientific meeting hosted by the American Society of Nephrology for participants to exchange knowledge, learn the latest scientific and medical advances, and participate in engaging discussions about kidney health and disease.

January 2018 Dr. Kamesh Surendran co-authored a manuscript published in Physiological Reports highlighting the expression and localization pattern of nonmuscle mysosin 2 isoforms in the renal epithelial cells of murine kidney. “Nonmuscle myosin 2 proteins encoded by Myh9, Myh10 and Myh14 are uniquely distributed in the tubular segments of murine kidney” 

November 2017 Dr. Kamesh Surendran and Malini Mukherjee presented current research findings on developmental signaling pathways of the kidney at the annual meeting of the American Society of Nephrology in New Orleans, LA. "Maintenance of mature collecting duct principal cells is dependent on Notch signaling."

March 2017 Kamesh Surendran, PhD, published a research article in Developmental Biology "Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression".

February 2017,Kamesh Surendran, PhD, served on a special emphasis review panel for the National Institute of Diabetes and Digestive and Kidney Disease.

November 2016, Dr. Surendran presented a poster entitled "Elf5 is a principal cell lineage specific transcription factor that contributes to normal expression of Aqp2 and Avpr2" at the 2016 American Society of Nephrology meeting in Chicago, IL.

November 2016, Dr. Kamesh Surendran gave an invited seminar entitled "A developmental biology approach to treating kidney diseases" at the University of Sioux Falls in Sioux Falls, SD.

July 2016, Dr. Kamesh Surendran received a $1.45 million R01 grant from the NIH's National Institute of Diabetes and Digestive and Kidney Diseases titled Molecular Regulators of Renal Collecting Duct Differentiation and Maintenance. These funds will be used to determine the essential transcriptional regulators that define the principal and intercalated cell types of the kidney collecting duct that are critical for water homeostasis and pH regulation. The knowledge gained will impact our understanding of both congenital/pediatric and acquired disorders of the collecting ducts such as Nephrogenic Diabetes Insipidus and renal tubular acidosis. These studies will also transform our understanding of kidney collecting duct cell differentiation and maintenance to provide knowledge that is fundamental to generating kidneys from patient-derived induced pluripotent-stem cells, which will improve the survival rates of end stage renal disease patients.