Lab News

May 2018 Jianning Tao was invited to give an oral presentation at the 2nd annual GMaP Region 6 Meeting at Huntsman Cancer Institute in Salt Lake City, UT. The title of his talk was "Identifying Driver mutation-interacting proteins in treatment of AYA cancers".The meeting was supported by Geographical Management of Cancer Health Disparities (GMaP) program at the National Cancer Institute.The goal of this meeting is to bring cancer and cancer disparities researchers, trainees and community partners together to discuss research, provide mentorship, and promote collaboration.

May 2018 Jianning Tao was invited to discuss his research program at the Cancer Biology Research Seminar at the University of California-Davis Comprehensive Cancer Center in Sacramento, CA. The title of his talk was "Cancer genes and pathways driving osteosarcoma development and metastasis"

May 2018 Jianning Tao received a grant from the GMaP 6 (Geographic Management of Cancer Health Disparities Program) region funded by the NIH National Cancer Institute. This research project focuses on identifying Notch1-interacting proteins that may serve as novel therapeutic targets in osteosarcoma.

April 2018 Jianning Tao was a co-author on a research paper published in Applied Materials Today demonstrating that engineered scaffolds containing hydroxyapatite and BMP2 mitogens increase bone formation and could be used for bone regeneration. “Functionalization of PCL-3D electrospun nanofibrous scaffolds for improved BMP2-induced bone formation” 

April 2018 Jianning Tao gave an invited presentation to the Department of Biomedical Engineering at the University of South Dakota. His presentation "The role of developmental signaling pathways in bone tumor formation" was attended by faculty, staff, and students at the Graduate Education and Applied Research Center at USD.

November 2017 Dr. Jianning Tao was invited to speak on his research program at St. Cloud State University. He presented on "Notching the skeleton: using genetically engineered mouse models to study bone cancer."

September 2017 Through recent funding support from SD EPSCoR and the Bio Systems Networks & Translational Research (BioSNTR), Dr. Jianning Tao is collaborating with Dr. Hongli Sun from The University of South Dakota to engineer a biomimetic nano-structured 3D bone niche to model cancer bone metastasis.

September 2017 Dr. Jianning Tao presented current research findings from his laboratory at the annual meeting of the American Society for Bone and Mineral Research (ASBMR) in Denver, CO. ASBMR is comprised of basic and clinical researchers investigating bone and mineral metabolism. Dr. Tao presented research updates from his laboratory on genetic pathways in bone cancer in a talk titled “Differentiation capacity of osteosarcoma cells transformed by distinct oncogenic drivers”.

September 2017, Dr. Tao attended the American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting in Denver, Co. The Tao Lab presented a poster entitled “Differentiation capacity of osteosarcoma cells transformed by distinct oncogenic drivers.”

August 2017, Kirby Rickel left the Tao Lab to study for her PhD at the Department of Biomedical Engineering at University of South Dakota.

May 2017 Dr. Jianning Tao co-authored a research article with colleagues from the Baylor College of Medicine in Nature Communications investigating how microRNAs regulate osteocyte differentiation during skeletal development.  "MicroRNA mir-23a cluster promotes osteocyte differentiation by regulating TGF-β signaling in osteoblasts."

January 2017 Dr. Jianning Tao received a research grant from BioSNTR for engineering a biomimetic nan-structured 3D bone niche to model cancer bone metastasis.

November 2016, The Tao laboratory published a paper entitled "Molecular genetics of osteosarcoma" in the journal Bone. https://www.ncbi.nlm.nih.gov/pubmed/?term=27760307

November 2016, Dr. Tao co-authored an article with Dr. Hongli Sun from the University of South Dakota entitled "Hypoxia-mimicking nanofibrous scaffolds promote endogenous bone regeneration" in the journal ACS Applied Materials & Interfaces. https://www.ncbi.nlm.nih.gov/pubmed/?term=27809470

November 2016, The Tao laboratory presented a poster entitled "Analysis of osteogenic and adipogenic differentiation potention of osteosarcoma cells transformed by Notch1 oncogene" at the 2016 American Society for Bone and Mineral Research meeting in Atlanta, GA.

August 2016, Using the genetically engineered animals, the Tao lab has shown that gain of function of Notch signaling in bone cells induced murine osteosarcoma and the causal role of Notch pathway functions through a Notch transcription complex that triggers downstream events to form bone tumor. The known components in the Notch complex include nuclear proteins such as NICD, Rbpj and MAML1 proteins. Ongoing studies by the team will identify novel components in the complex using the BioID approach and determine whether one of them may serves as a druggable target for cancer therapeutic intervention.

October 2015, Dr. Jianning Tao represented Sanford Research at the 2015 Annual Meeting of American Society for Bone and Mineral Research (ASBMR) at Seattle, WA.