Zhiguang Guo, MD, PhD, Lab


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At the clinical onset of type 1 diabetes (T1D), human patients still have some functional beta cell mass remaining. If we could control autoimmunity against beta cells, T1D may be cured by increasing the remaining β cell mass to restore normoglycemia. The goal of current research in my laboratory is to develop therapeutic approaches to treating T1D by ameliorating autoimmunity and by promoting beta cell survival and regeneration.

Primary Research Group

Secondary Research Groups

Our current research interests are focused on:

  1. Investigating human beta cell survival and regeneration in humanized mouse models with human islet grafts.
  2. Identifying non-coding RNAs as biomarkers to detect beta cell loss and to monitor the outcome of treatment in nonobese diabetic (NOD) mice, a mouse model of human T1D and in humanized mice with human islet grafts.
  3. Understanding therapeutically relevant mechanisms of modulating the inflammatory response and stimulating beta cell regeneration in NOD mice.
  4. Targeting G protein-coupled receptors using small molecular agonists alone and in combination with dipeptidyl peptidase-4 (DPP-IV) inhibitors to stimulate beta cell regeneration. 


Contact Information for Guo Lab:

Zhiguang Guo, MD, PhD 

The Sanford Project, Sanford Research
Associate Professor
Department of Pediatrics and Department of Surgery
Sanford School of Medicine
The University of South Dakota
Sanford Research Center
2301 East 60th Street North
Sioux Falls, SD 57104
Phone 605-312-6030 
Access Dr. Guo's publications here.