Lance Lee, PhD, Lab

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Primary Research Group

Pediatric & Rare Diseases

Secondary Research Groups

Environmental Influences on Health & Disease
Genetics & Genomics

 

Dr. Lee Bio

Lance Lee

  • Assistant scientist, Pediatric & Rare Diseases Group
Academic Affiliations
  • Associate professor in the Department of Pediatrics at the Sanford School of Medicine of the University of South Dakota

Primary Research Focus

Our research program is devoted to understanding how motile cilia function and how dysfunction results in pediatric disease. By identifying and understanding the underlying genetic and molecular mechanisms, we hope to advance the diagnosis and treatment of these disorders.

  

Behind the research

Motile cilia extend from the surface of specialized cells in the respiratory system, the reproductive system, the brain and the early embryo. These cilia play a critical role in clearance of fluid and particles over the surface of the cells, and the structurally related sperm flagella are required for sperm motility.

Dysfunction of cilia and flagella typically results in the pediatric syndrome primary ciliary dyskinesia (PCD), which affects approximately one in 16,000 live births. Affected individuals commonly suffer from chronic respiratory infections, chronic otitis media and male infertility, with situs inversus, hydrocephalus and female infertility also associated in some patients. While the importance of cilia and flagella in human health is clear, the molecular mechanisms underlying ciliary function are still under investigation.

In our laboratory, we use both traditional and emerging genetic approaches to elucidate the underlying causes of PCD and its associated disorders by identifying genes required for proper ciliary formation and function. We are also seeking to better understand the molecular mechanisms that regulate ciliary motility by applying cutting-edge biochemical and cell biological techniques to ciliated cells and disease models. As there is currently no cure for PCD, the goal of our research is to enable advancement of disease diagnosis and treatment and ultimately improve childhood health.

Contact Us  Positions available

Phone: (605) 312-6410

Fax: (605) 312-6071

Sanford Research
2301 E. 60th St. N.
Sioux Falls, SD 57104

Email: lance.lee@sanfordhealth.org

Join a dedicated team of researchers and help shape the future of motile cilia research. Contact Dr. Lee to inquire about open positions.