Publications

Xu Y, Yang X, Wang T, Yang L, He YY, Miskimins K, Qian SY (2018) Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism. BMC Cancer 27;18(1):330

Yang X, Xu Y, Wang T, Shu D, Guo P, Miskimins K, Qian SY (2017) Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells. Redox Biology 11;653-662

Yang, X, Xu, Y, Brooks, A, Guo, B, Miskimins, WK, Qian, SY (2016) Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. Free Radical Biology and Medicine 97:342-350.

Coppock, JD, Vermeer, PD, Vermeer, DW, Lee, KM, Miskimins, WK, Spanos, WC and Lee, JH (2016) mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC. Oncotarget, 7:24228-24241.

Halaby MJ, Harris BRE, Miskimins WK, Cleary MP, and Yang DQ. (2015) Molecular and Cellular Biology. 35(23):4006-17.

Halaby, M-J, Li, Y, Harris, B, Jiang, S, Miskimins, WK, Cleary, MP, and Yang, D-Q. (2015) "Translational control protein 80 stimulates IRES-mediated translation of p53 mRNA in response to DNA damage. BioMed Research International, 2015:708158.

Zhuang, Y, Chan, DK, Haugrud, AB, and Miskimins, WK. (2014) Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo. PLOS One, 9 (9): e108444.

Haugrud, AB, Zhuang, Y, Coppock, JD, and Miskimins, WK. (2014) Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin Treated Breast Cancer Cells. Breast Cancer Research and Treatment, 147(3):539-550.

Miskimins, WK,  Ryu, S, Jung, Y.-S, Choi, JY, Kim, JY, and Ahn, HJ. (2014) Synergistic Anti-cancer Effect of Phenformin and Oxamate. PLOS One. 9(1):e85576.

De P, Miskimins K, Dey N, Leyland-Jones B. (2013) Promise of rapalogues versus mTOR kinase inhibitors in subset specific breast cancer: old targets new hope. Cancer Treat Rev. 39(5):403-412.

Coppock JD, Wieking BG, Molinolo AA, Gutkind JS, Miskimins WK, Lee JH. (2013) Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 15(6):620-30.

Chan, DK, Miskimins WK (2012) Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures. J. Ovar. Res. 10;5(1):19.

Zheng Y, Miskimins WK (2011) Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site. Int J Biochem Cell Biol. 43(11):1641-1648.

Zheng Y, Miskimins WK (2011) CUG-Binding Protein Represses Translation of p27Kip1 mRNA Through Its Internal Ribosomal Entry Site. RNA Biol. 8(3):365-7.

Zhuang Y, Miskimins K (2011) Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells. Mol Cancer Res. 2011 Mar 21. [Epub ahead of print]

Smith NL, Miskimins WK (2011) Phosphorylation at Serine 482 Affects Stability of NF90 and its Functional Role in Mitosis. Cell Proliferation, 44(2):147-55.

Coleman J, Miskimins WK. Structure and activity of the internal ribosome entry site within the human p27(Kip1) 5'-untranslated region. RNA Biol. 6:84-89, 2009. (PMID: 19106631)

Zhuang Y, Miskimins WK. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin DI, and requires p27Kip1 or p21Cip1. Journal of Molecular Signaling 3:18, 2008. (PMID: 19046439)

Jiang H, Coleman J, Miskimins R, Srinivasan R, and Miskimins WK. Cap-independent translation through the p27 5'-UTR. Nucleic Acids Res. 35:4767-78, 2007. (PMID: 17617641)

Wei, Q., Eviatar-Ribak T, Miskimins W.K. and Miskimins R. Galectin-4 is involved in p27-mediated activation of the MBP promoter. J. Neurochem. 101:1214-1223, 2007. (PMID: 17403142)

Wei Q, Miskimins W.K., and Miskimins R. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. J. Biol. Chem. 280:16284-16294, 2005. (PMID: 15695521)

Wei, Q., Miskimins, W.K., and Miskimins, R. Sox10 Acts as a Tissue-Specific Transcription Factor Enhancing Activation of the Myelin Basic Protein Gene Promoter by p27Kip1 and Sp1. J. Neurosci. Res., 78:796-802, 2004. (PMID: 15523643)

Wang, G., Miskimins, R., and Miskimins, W.K. Regulation of p27Kip1 by intracellular iron levels. BioMetals, 17:15-24, 2004. (PMID: 14977358)

Wang, G., Reisdorph, R., Clark, R.E., Jr., Miskimins, R., Lindahl, R., and Miskimins, W.K. Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathway. J. Cell. Biochem., 90:548-60, 2003. (PMID: 14523989)

Jiang, H., Coleman, J., Miskimins, R., and Miskimins, W.K. Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breasr cancer cells. Cancer Cell International, 3:2, 2003. (PMID: 12633504)

Wei, W., Miskimins, W.K. and Miskimins, R. The Sp1 family of transcription factors is involved in p27Kip1-mediated activation of myelin basic protein gene expression. Mol. Cell. Biol., 23:4035-4045, 2003. (PMID: 12773549)

Wei, Q., Miskimins, W.K. and Miskimins, R. Cloning and characterization of the rat myelin basic protein gene promoter. Gene, 313:161-167, 2003. (PMID: 12957387)

Clark, R.E., Miskimins, W.K. and Miskimins, R. Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes. J. Neurochem., 83:565-573, 2002. (PMID: 12390518)

Clark, R.E., Miskimins, W.K. and Miskimins, R. Cyclic AMP inducibility of the myelin basic protein gene promoter requires the NF1 site. Int. J. Dev. Neurosci., 20:103-111, 2002. (PMID: 19106631)12034141

Miskimins, R.,, Srinivasan, R., Marin-Husstege, M., Miskimins, W.K. and Casaccia-Bonnefil, P. (2002) p27Kip1 enhances myelin basic protein gene promoter activity. J. Neurosci. Res. 67:100-105. (PMID: 11754085)

Coleman, J., Hawkinson, M., Miskimins, R. and Miskimins, W.K. (2001)The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5' UTR. BMC Molecular Biology 2:12. (PMID: 11696240)

Miskimins, W.K., Wang, G., Hawkinson, M. and Miskimins, R. (2001) Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation. Mol. Cell. Biol. 21:4960-4967. (PMID: 11438653)

Miskimins, R. and Miskimins, W.K. (2001) A role for an AP-1-like site in the expression of the myelin basic protein gene during differentiation. Intl. J. Dev. Neurosci. 19:85-91. (PMID: 11226757)

Wang, G., Miskimins, R. and Miskimins, W.K. (2000) Mimosine arrests cells in G1 by enhancing the levels of p27kip1. Exp. Cell Research. 254:64-71. (PMID: 10623466)

Wang, G., Miskimins, R. and Miskimins, W.K. (1999) The cyclin dependent kinase inhibitor p27kip1 is localized to the cytosol in Swiss/3T3 cells. Oncogene, 18:5204-5210. (PMID: 10498870)

Moore, B.A., Miskimins, R. and Miskimins, W.K. (1999) Involvement of ATF-1 in the induction of the transferrin receptor promoter in response to UV irradiation in B16 melanoma cells. Mol. Cell Biol. Res. Comm. 1:1-6. (PMID: 10329470)