Kyle Roux, PhD, Lab
Primary Research focus
To help reveal protein functions and mechanisms of disease we created the BioID method that generates a history of protein associations in living cells. BioID is a transformative method that has been adopted by hundreds of research groups worldwide to study a wide variety of proteins and biological processes including cancer, infectious disease, diabetes and rare diseases. Our laboratory used BioID to investigate the structure and function of the mammalian nuclear envelope in health and disease.
Behind the research
Defects in a cellular structure termed the nuclear envelope are associated with a myriad of diverse diseases, collectively called nuclear envelopathies. Most of these disorders clinically manifest during the first two decades of life and include muscular dystrophy, cardiomyopathy, lipodystrophy, dystonia, neuropathy, skeletal defects, and progeria. The nuclear envelope is situated at a critical juncture in the cell, both intimately associated with the genome and responsible for connecting it to the rest of the cell. While it is clear that mutations in genes encoding protein constituents of the nuclear envelope underlie these diseases, the exact mechanisms remain largely unknown. In part, these nuclear envelopathies involve a nuclear envelope structure called the LINC-complex that is responsible for linking the nucleoskeleton to the cytoskeleton.