Lab News

November 2017 Dr. Alexei Savinov co-authored an article in the Journal of Immunology and discovered a genetic region responsible that regulates pancreatic islet trafficking of autoreactive T cells which may represent a new therapeutic strategy for type 1 diabetes. “The type 1 diabetes-resistance locus Idd22 controls trafficking of autoreactive CTLs into the pancreatic islets of NOD mice”

October 2017 Dr. Alexei Savinov co-authored a research article published in PLoS One investigating calcification and lipid deposition in novel mouse models of coronary atherosclerosis. "Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model familial hypercholesterolemia."

October 2017 Dr. Alexei Savinov published a research article in Molecular Therapy demonstrating the therapeutic efficacy of a novel fusion protein with autoimmunity-preventing and insulin production-restoring properties in type 1 diabetes. "Self-transducible bimodal PDX1-FOXP3 protein lifts insulin secretion and curbs autoimmunity, boosting Tregs in type 1 diabetic mice."

October 2017 Drs. Alexei Savinov and Kurt Griffin received a research grant for $40,000 from the Sanford Health Foundation for their project titled "Chimeric T regulatory cells for type 1 diabetes treatment."

August 2017 Dr. Alexei Savinov along with Dr. Michelle Baack received a Mayo Collaboration grant for their project "Is the heterogenic mother mitochondrial DNA genome a cause of rejection in transplanted organs from cloned animals?"

July 2017 Dr. Alexei Savinov was a co-author on a collaborative research article with co-workers Drs. David Pearce, Jill Weimer, and Attila Kovacs published in Biochimica et Biphysica Acta investigating systemic effects such as infertility and immune dysfunction due to ataxia telangiectasia using a novel porcine model. "Genetic Ataxia Telangiectasia porcine model phenocopies the multisystemic features of the human disease"

July 2017 Dr. Alexei Savinov's laboratory presented current research findings at the annual meeting of the American Association of Clinical Chemistry in San Diego, CA. This work demonstrates that T-cell mediated autoimmunity in diabetes may be modulated by VISTA. "Investigating the regulatory role of a negative checkpoint molecule, VISTA in endothelial cells."

May 2017 Dr. Alexei Savinov gave a research presentation while attending a meeting in Cold Spring Harbor Laboratory in NY discussing Fundamental Immunology and its therapeutic potential. The goal of the meeting is to enhance fundamental immunology research while speeding the translation of clinic discoveries. Dr. Savinov discussed findings in his laboratory on the immunomodulatory T regulatory-inducing properties of individual VTCN1 domains.

April 2017 Alexei Savinov, PhD, was awarded a research grant from BioSNTR for his project, "Assessing Whole-cell PRPN22 interactome in macrophages."

May 2016, Dr. Alexei Savinov delivered an oral presentation entitled "Assessing whole-cell PTPN22 interactome in T cells with BioID" on April 28th at the Cold Spring Harbor Symposium on Gene Expression and Signaling in the Immune System in Cold Spring Harbor, NY.

January 2016, The laboratory of Dr. Alexei Savinov, including postdoctoral fellows Drs. Ilian Radichev and Lillianna Maneva-Radicheva and Sanford/USD graduate students Christina Amatya and Maryam Salehi, recently published a study from their laboratory entitled “Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes” in the Journal of Immunology.

December 2015, The Savinov team, including Drs. Alexei Savinov and Ilian Radichev and graduate student Maryam Salehi were co-authors on a recent publication in the Journal of the American Heart Association entitled “Transgenic Overexpression of Tissue-Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification.”