Jill Weimer, PhD, Lab

Weimer Lab

 Resources | PublicationsLab Members | Contact Us | Lab News | Lab Projects

Primary Research Group

Pediatrics & Rare Diseases

Secondary Research Group

Cellular Therapies & Stem Cell Biology
Enabling Technologies

 

Dr. Weimer Bio

  • Senior Director of Therapeutic Development
  • Associate Scientist, Pediatrics and Rare Diseases Group
Academic Affiliations
  • Associate Professor for the Department of Pediatrics, University of South Dakota Sanford School of Medicine

Primary Research Focus

Research in the Weimer Lab is focused on understanding the processes that control development of the cerebral cortex and how disruption in these processes leads to various neuropediatric diseases. Specifically, the team explores a number of mechanisms involved in neural stem cell proliferation, neuronal polarity, and axonal outgrowth and trafficking with the hope of advancing our knowledge of neurobiology and aiding in the future treatment of rare neural developmental disorders. This includes projects focused on Batten disease, cortical malformations, white matter disorders, neurofibromatosis, and Alzheimer’s disease.

Behind the research

Dr. Weimer’s research team is interested in understanding mechanisms of polarized signaling involved in development of the cerebral cortex.  These processes are known to regulate the proliferation and placement of neurons, formation of axons in differentiating cells, and long term maintenance and trafficking within these same processes. The Weimer lab draws on expertise in cell and molecular biology, genetics, and behavioral neuroscience to answer questions that bridge from basic mechanisms to translational and clinical approaches to treat human disease.  These questions answer how and why various scaffolding or “signaling complex” form in neurons, how disruption in these complexes can contribute to human disease and determine if these complexes may serve as druggable targets. 

Lab Projects

CRMP2/CLN6/KLC4: Mechanisms that mediate cargo selection and transport in developing & mature axons

MARCKS Associated Signaling Complexes in Cortical Development

Rho GTPase Signaling in the Developing Cerebral Cortex

Multifaceted preclinical studies for the treatment of Batten Disease

Contact Information Positions Available

Phone: (605) 312-6407

Email: jill.weimer@sanfordhealth.org

There are zero open positions within the Weimer lab at this time.