Primary Research Focus
Dr. Lance Lee’s research program is devoted to understanding how motile cilia function and how dysfunction results in pediatric disease. By identifying and understanding the underlying genetic and molecular mechanisms, they hope to advance the diagnosis and treatment of ciliary disorders.
Motile cilia extend from the surface of specialized cells in the respiratory system, the reproductive system, the brain and the early embryo. These cilia play a critical role in clearance of fluid and particles over the surface of the cells, and the structurally related sperm flagella are required for sperm motility.
Dysfunction of cilia and flagella typically results in the pediatric syndrome primary ciliary dyskinesia (PCD), which affects approximately one in 16,000 live births. Affected individuals commonly suffer from chronic respiratory infections, chronic otitis media and male infertility, with situs inversus, hydrocephalus and female infertility also associated in some patients. While the importance of cilia and flagella in human health is clear, the molecular mechanisms underlying ciliary function are still under investigation.
The Lee Lab uses both traditional and emerging genetic approaches to elucidate the underlying causes of PCD and its associated disorders by identifying genes required for proper ciliary formation and function. They also are investigating the molecular mechanisms that regulate ciliary motility by applying cutting-edge biochemical and cell biological techniques to mammalian ciliated cells and disease models. As there is currently no cure for PCD, the goal of their research is to enable advancement of disease diagnosis and treatment and ultimately improve childhood health.
About the Lee Lab
Lab Projects and News
Lee Lab Teaches Students About Cilia
Casey McKenzie shows regional high school students how the Lee Lab studies cilia and primary ciliary dyskinesia on a Sanford PROMISE Biomedical Research Investigation Day in October 2022.
Lee Lab Shares Research to Community Group
Lance Lee presents his research on primary ciliary dyskinesia to community members through the Osher Lifelong Learning Institute (OLLI) in September 2022.
McKenzie named Sanford Research Employee of the Year
Casey McKenzie was the 2022 recipient of the Ben Perryman Sanford Research Employee of the Year Award. This award is presented annually to a Sanford Research employee who embodies the mission and goals of Sanford Health.
Lee Presents Research at Pediatric Grand Rounds
Lance Lee presented lab research at Pediatric Grand Rounds in September 2016. Pediatric Grand Rounds lectures are geared toward increasing the knowledge base and clinical application of current standards of care for conditions identified as evolving and for emerging conditions. Registration is free. For registration questions, contact Brenda Ramstad by calling (605) 312-9230 or by email.
Lee Lab Presents at National Biology Conference
Postdoctoral fellow Rozzy Finn presented her research at the Experimental Biology Conference in San Diego in April 2014. Experimental Biology is the annual meeting of five societies composed of more than 14,000 scientists and 25 guest societies. Primary focus areas include anatomy, biochemistry and molecular biology, investigative pathology, pharmacology and physiology. Attendees represent scientists from academic institutions, government agencies, nonprofit organizations and industry. This multidisciplinary, scientific meeting features plenary and award lectures, workshops, oral and posters presentations, on-site career services and exhibits spotlighting equipment, supplies and publications required for research labs and experimental study.
Undergraduate Lab Researcher Presents at National Conference
Summer undergraduate student Katherine Johnson presented her project at the Experimental Biology Conference in San Diego in April 2014. Experimental Biology is the annual meeting of five societies composed of more than 14,000 scientists and 25 guest societies. Primary focus areas include anatomy, biochemistry and molecular biology, investigative pathology, pharmacology, and physiology. Attendees represent scientists from academic institutions, government agencies, non-profit organizations and industry. This multidisciplinary, scientific meeting features plenary and award lectures, workshops, oral and posters presentations, on-site career services and exhibits spotlighting equipment, supplies and publications required for research labs and experimental study.