Immune Response
Lee DW, Anderson ME, Wu S, Lee, JH, Development of an Adenoviral Vaccine Against E6 and E7 oncoproteins to prevent growth of human papillomavirus—postive cancer. Arch Otolaryngol Head Neck Surg, 2008 Dec; 134 (12). 1316-23. PMID 19075129
Williams R, Lee DW, Elzey BD, Anderson ME, Hostager BS, Lee JH, Preclinical models of HPV+ and HPV- HNSCC in mice: An immune clearance of HPV+ HNSCC. Head Neck. 2009 Mar 12. [Epub ahead of print] PMID 19283850
Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators.Park WS, Ryu J, Cho KH, Choi MK, Moon SH, Yun T, Chun BS, Lee GK, Ahn HJ, Lee JH, Vermeer P, Jung YS.Head Neck. 2011 Nov 2. doi: 10.1002/hed.21939. PMID:22052559
Goforth R, Salem AK, Zhu X, Miles S, Zhang XQ, Lee JH, Sandler AD. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma. Cancer Immunol Immunother. 2009 Apr; 58(4):517-30. Epub 2008 Aug 22. PMID: 18719913
Spanos WC, Nowicki P, Lee DW, Hoover A, Hostager B, Gupta A, Anderson ME, Lee JH. Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer. Arch Otolaryngol Head Neck Surg. 2009 Nov; 135(11): 11371146. PMID: 19917928
HPV transformation
Vermeer, P.D., Bell, M., Lee, K., Vermeer, D.W., Wieking, B.G., Bilal, E., Bhanot, G., Drapkin, R.I., Ganesan, S., Klingelhutz, A.J., Hendricks, W.J., Lee, J. ErbB2, EphrinB1, Src Kinase and PTPN13 Signaling Complex regulates MAP Kinase signaling in human cancers. Plos One Jan 18, 2012.
Hoover AC, Spanos WC, Harris GF, Anderson ME, Klingelhutz AJ, Lee JH. The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium. Arch Otolaryngol Head Neck Surg. 2007 May; 133(5):495-502. PMCID: PMC2917346
Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang DH, Haugen TH, Turek LP. Age, Sexual Behavior and Human Papillomavirus Infection in Oral Cavity and Oropharyngeal Cancers. Int J of Cancer 2004; 108:766-772. PMID: 14696105
Lee JH, Yi SP, Anderson ME, Berger KL, Welsh MJ, Klingelhutz AJ, Ozbun MA. Propagation of Infectious Human Papillomavirus Type 16 Using a Novel Adenovirus and Cre/LoxP Mechanism. PNAS 2004; 101(7):2094-2099. PMCID: PMC357057
James MA, Lee JH, Klingelhutz AJ. Human Papillomavirus Type 16 E6 Activates NF-κB, Induces cIAP-2 Expression, and Protects Against Apoptosis in a PDZ Binding Motif-Dependent Manner. Journal of Virology 2006 March; 80(11). PMCID: PMC1472131
James MA, Lee JH, Klingelhutz AJ. HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells, and enhanced by loss of p300. Int J Cancer 2006 Oct 15; 119(8):1878-85. PMCID: PMC2223064
Spanos WC, Hoover A, Harris GF, Wu S, Strand G, Anderson ME, Klingelhutz AJ, Hendriks W, Bossler AD, Lee JH. The PDZ binding motif of HPV 16 E6 induces PTPN13 loss which allows anchorage independent growth and synergizes with Ras for invasive growth. J Virol 2008 Mar; 82(5):2493-500. Epub 2007 Dec 26. PMCID: PMC2258903
Spanos WC, Geiger J, Anderson ME, Harris GF, Bossler AD, Smith RB, Klingelhutz AJ, Lee JH. Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head Neck 2008 Feb; 30(2):139-47. PMCID: PMC2600880
Hoover AC, Strand GL, Nowicki PN, Anderson ME, Vermeer PD, Klingelhutz AJ, Bossler AD, Piottala JV, Hendriks W, Lee JH. Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene 2009 Sept 7. PMCID: PMC2785129
Lace, MJ, Anson, JR, Klingelhutz, AJ, Lee, JH, Bossler, AD, Haugen, TH, Turek, LP. Human Papillomavirus (HPV) Type-18 Induces Extended Growth in Primary Human Cervical, Tonsillar or Foreskin Keratinocytes More Effectively Than Other High-Risk Mucosal HPVs. J Virology 2009 Sept 9; PMID: 19740985 |