Liang Lab Publications

Chen K, Xu X, Kobayashi S, Timm D, Jepperson T, and Liang Q. Caloric restriction mimetic 2-deoxy-glucose antagonizes doxorubicin-induced cardiomyocyte death through multiple mechanisms. J Biol  Chem. 2011 Jun 24;286(25):21993-2006. Epub 2011 Apr 26. PMID:21521688

Tang M, Li J, Huang W, Su H, Liang Q, Tian Z, Horak KM, Molkentin JD, and Wang X. Proteasome Functional Insufficiency Activates the Calcineurin-NFAT Pathway in Cardiomyocytes and Promotes Maladaptive Remodeling of Stressed Mouse Hearts. Cardivas Res.  2010 Dec 1;88(3):424-33. Epub 2010 Jul 2. PMID:20601385

Kobayashi S, Volden P, Timm D, Mao K, Xu X, Liang Q. Transcription factor gata4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem. 2010 Jan; 1;285(1): 793-804. Epub 2009 Nov 9.

Huang Y, Kobayashi S, Eglethun M, Wright C, Liang Q, and O’Connell TD. GATA4 is a Survival Factor in Adult Cardiac Myocytes, but Is Not required for alpha1A-Adrenergic Receptor Survival Signaling, Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H699-707. Epub 2008 Jun 13.

Mao K, Kobayashi S, Huang Y, Jaffer ZM, Chernoff J, Volden P, and Liang Q. Regulation of Akt/PKB activity by P21 activated kinase in cardiac myocytes. J Mol Cell Cardiol. 2008 Feb;44(2):429-34. Epub 2007 Dec 3.

Chen Y, Kobayashi S, Redetzke R, Said S, Liang Q, and Gerdes AM. Short-term Triiodo-L-Thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J Mol Cell Cardiol. 2008 Jan;44(1):180-7. Epub 2007 Oct 26.

Kobayashi S, Mao K, Zheng H, Wang X, Patterson C, O’Connell TD and Liang Q. Diminished GATA4 Protein Levels Contribute to Hyperglycemia-induced Cardiomyocyte Injury. J Biol Chem. 2007 Jul 27; 282(30):21945-21952. Epub 2007 May 24.

Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, and O’Connell. An alpha1A- adrenergic- extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007 Feb 13;115(6):763-72. Epub 2007 Feb 5.

Liang Q, Elson A, and Gerdes AM. P38 MAP kinase activity is correlated with Angiotensin II Type 1 Receptor Blocker induced Left Ventricular Reverse Remodeling in Spontaneously Hypertensive Heart Failure Rats. J Card Failure. 2006 Aug;12(6):479-86.

Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, and Liang Q. Transcription Factor Gata4 Regulates Cardiac Bcl2 Gene Expression In Vitro And In Vivo. FASEB J. 2006 Apr; 20(6):800-2. Epub 2006 Feb 9.

Kuzman JA, Gerdes AM, Kobayashi S, and Liang Q. T3 Activates AKT and Prevents Serum Starvation Induced Cell Death in Neonatal Cardiomyocytes. J Mol Cell Cardiol. 2005 Nov; 39(5):841-4.

Liang Q, Kaiser RA, Bueno OF, Huang Y, Lackey T, Klevitsky R, Hewett TE, Molkentin JD. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem. 2005 Sep; 23;280(38):32602-8.

Liang Q, and Molkentin JD. Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. J Mol Cell Cardiol. 2003 Dec; 35(12):1385-94.

Liang Q, Bueno OF, Wilkins BJ, Kuan CY, Xia Y, Molkentin JD. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J. 2003 Oct 1;22(19):5079-89.

Suzuki YJ, Day RM, Tan CC, Sandven TH, Liang Q, Molkentin JD, and Fanburg BL. Activation of GATA4 by serotonin in pulmonary artery smooth muscle cells. J Biol Chem. 2003 May 9; 278(19):17525-31.

Braz JC, Bueno OF, Liang Q, Wilkins B, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, and Molkentin JD. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest. 2003 May; 111(10):1475-86.

Sanbe A, Gulick J, Hanks MC, Liang Q, Osinska H and Robbins J. Reengineering Inducible Cardiac-specific Transgenesis with an Attenuated Myosin Heavy Chain Promoter. Circ Res. 2003 Apr 4; 92(6):609-16.

Liang Q, and Molkentin JD. Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression. J Mol Cell Cardiol. 2002 Jun;34(6):611-6.

Liang Q, Donthi RV, Kralik PM, and Epstein PN. Elevated hexokinase increases cardiac glycolysis in transgenic mice. Cardiovasc Res 2002 Feb 1; 53(2):423-30.

Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, and Epstein PN. Overexpression of metallothionein reduces diabetic cardiomyopathy. Diabetes 2002 Jan; 51(1):174-81.

Liang Q, Wiese RJ, Bueno OF, Dai YS, Markham BE, and Molkentin JD. The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Mol Cell Biol 2001 Nov; 21(21):7460-9.

Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, and Molkentin JD, Meloche S, and Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev. 2001 Oct 15;15(20):2702-2719.

Liang Q, De Windt LJ, Witt SA, Kimball TR, Markham BE, and Molkentin JD. The transcriptional factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem 2001 Aug 10; 276(32):30245-53.

De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, and Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A 2001 Mar 13; 98(6):3322-3327.

Liang Q, Carlson EC, Borgerding AJ, and Epstein PN. A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. J Pharmacol Exp Ther 1999 Nov; 291(2):766-72.