O'Connell Lab Publications

O'Connell Lab Publications Since 2001

O'Connell TD, Rokosh DG, and Simpson PC. 2001. Cloning and characterization of the mouse alpha1C-adrenergic receptor gene: An M-CAT element is required for promoter activity in cardiac myocytes. Mol. Pharmacol. 59(5): 1225-1234.

McCloskey DT, Rokosh DG, O'Connell TD, Keung EC, Simpson PC and Baker AJ. 2002. Alpha1-adrenoceptor subtypes mediate negative inotropy in myocardium from alpha1A/C-knockout and wild type mice. J. Mol. Cell. Cardiol. 34: 1007-1017.

Gilman AG et al. 2002. Overview of the Alliance for Cellular Signaling. Nature 420:703-706.

Sambrano GR, Fraser I, Han H, Ni Y, O'Connell TD, Yan Z, and Stull JT. 2002 Navigating the signaling network in mouse cardiac myocytes. Nature 420:712-714.

Hsueh R, Roach T, Lin KM, O'Connell TD, and Yan Z. 2002. Purification and characterization of mouse splenic B lymphocytes. AfCS Research Reports.

Turnbull L, McCloskey DT, O'Connell TD, Simpson PC and Baker AJ. 2003. Alpha1-Adrenergic receptor responses in alpha1-AB-AR knockout mouse hearts suggest the presence of alpha1D-AR. Am. J. Physiol. (Heart Circ. Physiol.) 284: H1104-H1109.

O'Connell TD, Ishizaka S, Nakamura A, Swigart PS, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E and Simpson PC. 2003. Double knockout of the alpha1A/C and alpha1B-adrenegic receptor subtypes: alpha1-Adrenregic receptors are required for cardiac hypertrophy during postnatal development. J. Clin. Invest. 111: 1783-1791.

McCloskey DT, O'Connell TD, Simpson PC and Baker AJ. 2003. Abnormal myocardial contraction in alpha1A- and alpha1B-adrenoceptor double knockout mice. J. Mol. Cell. Card. 35: 1207-1216.

O'Connell TD, Ni YG, Lin K M, Han H, and Yan Z. 2003. Isolation and culture of adult mouse cardiac myocytes for signaling studies. AfCS Research Reports.

Okoshi, MP, Yan X, Okoshi K, Nakayama M, Schuldt AJ, O'Connell TD, Simpson PC and Lorell BH. 2004. Aldosterone directly stimulates cardiac myocyte hypertrophy. J. Card. Fail. 10: 511-518.

O'Connell TD, Swigart PS, Rodrigo MC, Ishizaka S, Joho S, Foster E, Grossman W, and Simpson PC. 2006, Alpha1-Adrenregic receptors prevent a maladaptive response to pressure overload. J. Clin. Invest. 116: 1005-1015.

O'Connell TD, Rodrigo MC and Simpson PC. 2007. Isolation and culture of adult mouse cardiac myocytes. In Cardiovascular Proteomics: Methods and Protocols. F. Vivanco, editor. Totowa, NJ: Humana Press. 271-296.

Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC and O'Connell TD. 2007. An alpha1A-adrenergic-ERK survival signaling pathway in cardiac myocytes. Circulation. 115: 763-772.

Kuzman JA, O'Connell TD, and Gerdes AM. 2007. Rapamycin prevents thyroid hormone induced cardiac hypertrophy. Endocrinol. 148: 3477-3484.

Kobayashi S, Mao K, Zheng H, Wang X, Patterson C, O'Connell TD, and Liang Q. 2007. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. J. Biol. Chem. 282: 21945-21952.

Huang Y, Wright CD, Kobayashi S, Healy CL, Elgethun M, Cypher, A, Liang Q and O'Connell TD. 2008. GATA4 Is a Survival Factor in Adult Cardiac Myocytes, but Is Not Required for alpha1A-Adrenergic Receptor Survival Signaling. Amer. J. Physiol. Heart Circ. Physiol. 295: H699-707.

Wright CD, Chen Q, Baye NL, Huang Y, Healy CL, Kasinathan S, and O'Connell TD. 2008. Nuclear alpha1-Adrenergic Receptors Signal Activated ERK Localization to Caveolae in Adult Cardiac Myocytes. Circ. Res. 103: 992-1000.

Wright C.D., S.C. Wu, E.F. Dahl, A.J. Sazama, and T.D. O'Connell. Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal. 2012 Mar;24(3):794-802. PMID: 22120526

NIH's PubMed Home website

Quick Links

External Sites

Major Medical Centers

Contact Us

Sanford Research/USD

Sanford Center
2301 East 60th Street North
Sioux Falls, SD 57104
Office: (605) 312-6300

email@sanfordresearch.org

Follow Us!

©2012 Sanford Health. All rights reserved.