Ratan Bhardwaj, MD, Lab
Behind the research
Regenerative medicine holds great promise in the years ahead. Dr. Bhardwaj’s past research was focused on stem cell dynamics in adult human organs. The Bhardwaj Lab will focus efforts on studying the potential of cellular plasticity, by manipulating the epigenetic landscape and non-coding milieu. The team will investigate umbilical cord cells’ transdifferentiation potential under various biophysical and molecular manipulations.
Pediatric brain tumors represent a true challenge to children and their families. The Bhardwaj Lab has discovered novel molecular biological pathways in ATRT - a notoriously difficult tumor type to successfully treat. The team will use various compounds in current trials for other malignancies, to better treat and possibly cure this horrible cancer. Established industry collaborators partner in this work. Dr. Bhardwaj and his team will use combinations of cell lines, siRNA knock down, Western blots, immunoprecipitation, and flow cytometry to tackle this tumor type.
May 2017, Dr. Ratan Bhardwaj published a research article in Molecular Cancer Research identifying differential protein tyrosine kinase expression in atypical teratoid rhabdoid tumors (ATRT) and demonstrating that inhibition of PTK7 decreased survival of ATRT-derived tumor cells. “Therapeutic targeting of PTK7 is cytotoxic in atypical teratoid rhabdoid tumors”
November 2016,Dr. Bhardwaj was awarded a grant from SD BioSNTR for his research project entitled "Computational modeling and single cell transcriptomic profiling in Atypical Teratoid Rhabdoid Tumor (ATRT)."
August 2016, Dr. Ratan Bhardwaj has contributed a chapter to a book entitled Pediatric Brain Stimulation - Mapping and Modulating the Developing Brain which was recently published by Academic Press. His chapter was focused on “Deep brain stimulation in children – surgical consideration.”