Kevin Francis, PhD, Lab

 Milanovich Lab

Resources | Contact Us | Lab News | Lab Members | Lab Projects

Primary Research Group

Secondary Research Groups

 

Dr. Francis Bio

Sam Milanovich

  • Assistant scientist in the Children's Health Research Center
  • Assistant professor in the Department of Pediatrics, Sanford School of Medicine at the University of South Dakota
  • Bachelor of Science in biology at Marshall University, Huntington, WV
  • Master of Science in anatomy at the University of Georgia, Athens, GA
  • Doctorate in neuropathology at the Medical University of South Carolina, Charleston, SC
  • Postdoctoral fellowship at the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD

Primary Research Focus

Using cellular and animal models which enable us to dissect cell-specific and time-dependent cellular mechanisms, we are resolving the functional and developmental consequences of molecular interactions to better understand how genetic changes result in disease initiation and progression. Research in the Francis lab primarily takes advantage of the process of cellular reprogramming to generate induced pluripotent stem cells (iPSCs) from patients exhibiting rare diseases, allowing us to model these diseases, identify cellular phenotypes, and delineate disease mechanisms in the laboratory. Using a variety of technical approaches, our goals are to define the cellular mechanisms underlying rare diseases resulting from various genetic mutations, identifying signaling pathways and targets amenable to patient therapy.

Behind the research

Dr. Francis’ current research projects are focused on rare pediatric disorders of cholesterol synthesis and trafficking. Using genetic mouse models and iPSCs derived from patients diagnosed with these rare disorders, we are examining how cholesterol and cholesterol precursors interact with developmentally critical signaling pathways, such as the Wnt and Sonic Hedgehog signaling pathways, to affect neural development, cellular function and disease pathogenesis. A wide array of experimental techniques is utilized within the laboratory including non-integrating cellular reprogramming methods of various cell types, immunocytochemistry, whole genomic sequencing, high-throughput screening methods and standard molecular biology and biochemical assays.

A number of ongoing collaborations with researchers at Sanford Research, USD, and SDSU, as well as external collaborators at the University of Tennessee Health Sciences Center, University of Illinois at Chicago and Sanford-Burnham-Prebys Medical Discovery Institute, are harnessing the power of reprogramming technology for the study of other rare disorders affecting neurodevelopment and function. These projects and others are also delving into basic biological questions regarding how lipid metabolism regulates normal developmental processes and cellular function.

Projects

Mechanisms underlying neural phenotypers of cholesterol synthesis disorder
 

Resources

Access Dr. Francis' publications here.

Meet members of the Francis lab here.

 

Contact Us

Phone: (605) 312-6422 

Email: kevin.francis@sanfordhealth.org

 

Positions Available  
Join a dedicated team of researchers and help shape the future of pediatric rare disease research. See open positions here.  
 
 

 

Lab News

May 2017 Dr. Kevin Francis received a research grant from the Sanford Health Foundation for the Cellular Therapies and Stem Cell Biology Pilot Grant.

April 2017 Kevin Francis, PhD, was invited to present as part of a plenary session at the annual meeting of the German Society of Human Genetics in Bochum, Germany. The German Society of Human Genetics is the primary professional membership organization for over 1,000 German researchers, academic clinicians, laboratory practice professionals and genetic counselors. Dr. Francis presented on "Modeling disorders of sterol biosynthesis with reprogrammed stem cells."

February 2017, Kevin Francis, PhD, was invited to give a research seminar to students and faculty at Augustana University in Sioux Falls, SD. The title of his seminar was "Stem cell models of neurodevelopment: New hope for rare disease".

February 2017, Kevin Francis, PhD, presented an invited workshop titled "Modeling rare neurological disorders with reprogrammed stem cells" to students and faculty at the Center for Brain and Behavior Research at the University of South Dakota in Vermillion.

October 2016, Dr. Francis gave a research presentation entitled "Stem cell research and therapies: Fact vs Fiction" at the 2016 SD Chapter meeting of the American Academy of Professional Coders in Sioux Falls, SD.

News Archive.