Microarray Data

This is the data is the full data set that appeared in the following publications:

 

Chattopadhyay, S., Ito, M., Cooper, J. D., Brooks, A. I., Curran, T. M., Powers, J. M. and Pearce, D. A. (2002). An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegeneartive disorder Batten disease. Hum. Mol. Genet. 11 , 1421-1431.

Bijlani, R., Chen, Y., Brooks, A. I., Pearce D. A. and Ogihara, M. (2002). Prediction of biologically significant components from microarray data: Independently Consistent Expression Discriminator (ICED). Bioinformatics. 19, 62-70.

Brooks, A. I, Chattopadhyay, S, Mitchison, H. M, Nussbaum, R. L and Pearce, D.A. (2003). Functional Categorization of Gene Expression Changes in the Cerebellum of a Cln3-Knockout Mouse Model for Batten Disease. Mol. Gen Metab. 78, 17-30.


 This is the data is the full data set that appeared in the following publication:

Results from 10 week old whole brain cln1- and cln3-knockout mice > 1-5 fold change, pvalue < 0.05

Gene expression changes in the whole brain of cln1-knockout mice < 1-5 fold change, pvalue <0.05.

Gene expression changes in the whole brain of cln3-knockout mice < 1-5 fold change, pvalue <0.05.

Elshatory, Y, Brooks, A. I, Chattopadhyay, S, Curran, T. M, Gupta, P, Ramalingam, V, Hofmann, S. L. and Pearce, D. A. (2003). Early Changes in Gene Expression in Two Models of Batten Disease. FEBS Lett. 538, 207-212.


This is the data is the full data set that appeared in the following publication:

 

Chattopadhyay, S., Kingsley, E., Serour, A., Curran, T. M., Brooks, A. I., and Pearce, D. A. (2004). Altered Gene Expression in the Eye of a Mouse Model for Batten Disease. IOVS. 45, 2893-2905.