Publications

SAVINOV A.Y., and Burn P. Interference with islet-specific homing of autoreactive T cells: an emerging therapeutic strategy for type 1 diabetes Drug Discovery Today 15: 531-539 (2010)

Shiryaev S.A., Remacle A.G., SAVINOV A.Y., Chernov A.V., Cieplak P., Radichev I.A., Williams R., Shiryaeva T.N., Gawlik K., Postnova T.I., Ratnikov B.I., Eroshkin A.M., Motamedchaboki K., Smith J.W., and Strongin A.Y. Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis. J Biol Chem. 2009 Oct 30;284(44):30615-26.

Rozanov D.V., SAVINOV A.Y., Golubkov V.S., Rozanova O.L., Postnova T.I., Sergienko E.A., Vasile S., Aleshin A.E., Rega M.F., Pellecchia M., and Strongin A.Y. Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells. Mol Cancer Ther. 2009 Jun;8(6):1515-25.

Lee S-H., Hao E., SAVINOV A.Y., Geron I., Strongin A.Y., and Itkin-Ansari P. Human β−cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies. Transplantation. 2009. 87(7):983-91.

Shiryaev S.A., SAVINOV A.Y., Cieplak P., Ratnikov B.I., Motamedchaboki K., Smith J.W., and Strongin A.Y. Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis. PLoS ONE. 2009. 4(3):e4952.

SAVINOV A.Y. and Strongin A.Y. Matrix metalloproteinases, T cell homing and β-cell mass in type 1 diabetes. Vitamins & Hormones. Vitam Horm. 2009. 80:541-62.

Rozanov D.V., SAVINOV A.Y., Williams R., Liu K., Golubkov V.S., Krajewski S., and Strongin A.Y. Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer. Cancer Res. 2008. 68(11):4086-96.

Johnson S.L., Chen L.H., Harbach R., Sabet M., SAVINOV A, Cotton N.J., Strongin A., Guiney D., and Pellecchia M. Rhodanine derivatives as selective protease inhibitors against bacterial toxins. Chem Biol Drug Des. 2008. 71(2):131-9.

SAVINOV A.Y., Rozanov D.V., and Strongin A.Y. Specific inhibition of autoimmune T cell transmigration contributes to beta -cell functionality and insulin synthesis in non-obese diabetic (NOD) mice. J. Biol. Chem. 2007. 282(44):32106-11.

Shiryaev S.A., Remacle A.G., Ratnikov B.I., Nelson N.A., SAVINOV A.Y., Wei G., Bottini M., Rega M.F., Parent A., Desjardins R., Fugere M., Day R., Sabet M., Pellecchia M., Liddington R.C., Smith J.W., Mustelin T., Guiney D.G., Lebl M., and Strongin A.Y. Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem. 2007. 282(29):20847-53.

SAVINOV A.Y., and Strongin A.Y. Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes IUBMB Life. 2007. Jan;59(1)L6-13.

Golubkov V.S., Chekanov A.V., SAVINOV A.Y., Rozanov D.V., Golubkova N.V., and Strongin A.Y. Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells. Cancer Res. 2006. 66(21):10460-5.

SAVINOV A.Y., Rozanov D.V., and Strongin A.Y. Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes. FASEB J. 2006. 20(11):1793-801.

Rozanov D.V., SAVINOV A.Y., Golubkov V.S., Tomlinson S., and Strongin A.Y. Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res. 2006. 66(12):6258-63.

Remacle A.G., Chekanov A.V., Golubkov V.S., SAVINOV A.Y., Rozanov D.V., and Strongin A.Y. O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP). J Biol Chem. 2006. 281(25):16897-905.

SAVINOV A.Y., Remacle A.G., Golubkov V.S,. Krajewska M., Kennedy S., Duffy M.J., Rozanov D.V., Krajewski S., and Strongin A.Y. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res. 2006. 66(5):2716-24.

Chekanov A.V., Remacle A.G., Golubkov V.S., Akatov V.S., Sikora S., SAVINOV A.Y., Fugere M., Day R., Rozanov D.V., and Strongin A.Y. Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: A putative mechanism to overcome a furin deficiency. Arch. Biochem. Biophys. 2006. 446(1):52-9.

Forino M., Johnson S., Wong T.Y., Rozanov D.V., SAVINOV A.Y., Li W., Fattorusso R., Becattini B., Orry A.J., Jung D., Abagyan R.A., Smith J.W., Alibek K., Liddington R.C., Strongin A.Y., and Pellecchia M. Efficient synthetic inhibitors of anthrax lethal factor. Proc. Natl. Acad. Sci. U S A. 2005. 102(27):9499-504.

SAVINOV A.Y., Rozanov D.V., Golubkov V.S., Wong F.S., and Strongin A.Y. Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. J. Biol. Chem. 2005. 280(30):27755-8.

Golubkov V.S., Boyd S., SAVINOV A.Y., Chekanov A.V., Osterman A.L., Remacle A., Rozanov D.V., Doxsey S.J., and Strongin A.Y. Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability. J. Biol. Chem. 2005. 280(26):25079-86.

Li W., SAVINOV A.Y., Rozanov D.V., Golubkov V.S., Hedayat H., Postnova T.I., Golubkova N.V., Linli Y, Krajewski S., and Strongin A.Y. Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin. Cancer Res. 2004. 64(23):8657-65.

Rozanov D.V., SAVINOV A.Y., Golubkov V.S., Postnova T.I., Remacle A., Tomlinson S.W., and Strongin A.Y. Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system. J. Biol. Chem. 2004. 279(45):46551-7.

Rozanov D.V., Sikora S., Godzik A., Postnova T.I., Golubkov V., SAVINOV A., Tomlinson S., and Strongin A.Y. Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q. J. Bio.l Chem. 2004. 279(48):50321-8.

SAVINOV A.Y., Wong F.S., Stonebraker A.C., and Chervonsky A.V. Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specifc CD8+ T cells J. Exp. Med. 2003. 197(5): 643-656.

SAVINOV A.Y., Tcherepanov A., Green E.A., Flavell R.A., and Chervonsky A.V. Contribution of Fas to diabetes development. Proc. Natl. Acad. Sci. U S A. 2003. 100(2): 628-32.

SAVINOV A.Y., Wong F.S., and Chervonsky A.V. IFN-gamma affects homing of diabetogenic T cells. J. Immunol. 2001. 167(11): 6637-43.

Mathews C.E., Graser R.T., SAVINOV A., Serreze D.V., and Leiter E.H. Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants. Proc. Natl. Acad. Sci. U S A. 2001. 98(1): 235-40.

Liu Y., McMinimy D.L., SAVINOV A.Y., Johnson K.A., Kremlev S.G., Chapoval A.I., Egorov I.K. Hidden variables: unstable Abeta chain genes encoding antigen recognition structures in tumor survivors. Mol. Immunol. 2000. 37(18): 1091-110.

Liu Y., SAVINOV A.Y., McMinimy D.L., Kremlev S.G., Chapoval A.I., Egorov I.K. The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-Radiats. Biol. Radioecol. 2000. 40(5): 500-5.

Nakamura J., SAVINOV A., Lu Q., Brodie A. Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology. 1996. 137(12): 5589-96.

Lu Q., Nakmura J., SAVINOV A., Yue W., Weisz J., Dabbs D.J., Wolz G., Brodie A. Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology. 1996. 137(7): 3061-8.

Yue W., Wang J., SAVINOV A., Brodie A..Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model. Cancer Res. 1995. 55(14): 3073-7.

SAVINOV A.Yu., Tcherepanov A.A., Dambinova S.A. The role of non-MNDA type of glutamate receptors in the pathogenesis of epilepsy. Epilepsia (Int.) 1995. 74: 1232-39.

Lebedev L.V., Gusinsky A.V., Smirnov A.D., Sharova O.L., Galebskaya L.V., Sockurenko G.Yu., SAVINOV A.Yu., Vinogradov A.G., Gordeev N.A., Dmitrievskaya N.O. The novel method of development and production of xenoangiotransplant. Description for the international patent # RU 2026618 invented in Russian Federation, 1995.

Dambinova S.A., Bobryshev Iu.V., Gorodinskii A.I., Margulis M.N., Nikitin A.O., Orlova E.A., Pavlov I.Iu., SAVINOV A.Iu. The pharmacological characteristics, immunochemical identification and study of the location of quisqualate receptors in the rat and human brains. Zh. Evol. Biokhim. Fiziol. 1992. (2): 201-10. Russian.

Dambinova S.A., Gorodinsky A.I., Doemina M.N., Oleinikov A.P., SAVINOV A.Yu., Krivosheina Yu.P., Epilepsy immunodiagnostics: the perspectives for the risk-group revealing. - in "Fundamental science for the medicine" edited by N.,P., Bekhtereva, (Russ.) Leningrad,"Meditsina", 1990.