Adam10 Mediates the Choice between Principal Cells and Intercalated Cells in the Kidney
Guo Q, Wang Y, Tripathi P, Manda KR, Mukherjee M, Chaklader M, Austin PF, Surendran K*, Chen F*.
J Am Soc Nephrol. 2014 Jun 5. [Epub ahead of print] PMID:24904084 [PubMed - as supplied by publisher]
*co-corresponding authors.

Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012;8(3):e1002577. doi: 10.1371/journal.pgen.1002577. Epub 2012 Mar 22.

Surendran K, Selassie M, Liapis H, Krigman H, Kopan R. Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol. 2010 May;21(5):819-32. 

Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McBright B, Kopan R. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Developmental Biology. 2010 Jan;337(2):386-95.

Lin CL, Wang JY, Ko JY, Surendran K, Huang YT, Kuo YH, Wang FS. Superoxide destabilization of beta-catenin augments apoptosis of high-glucose-stressed mesangial cells. Endocrinology. 2008 Jun;149(6):2934-42.

Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007 Feb;134(4):801-11

Lin CL, Wang JY, Huang YT, Kuo YH, Surendran K, Wang FS. Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol. 2006 Oct;17(10):2812-20.

Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-Catenin signaling is activated after unilateral ureteral obstruction, and recombinant Secreted Frizzled-Related Protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol. 2005 Aug;16(8):2373-84.

Surendran K, Simon TC, Liapis H, McGuire JK. Matrilysin (MMP-7) expression in renal Tubular damage: Association with Wnt4. Kidney Int. 2004 Jun;65(6):2212-22.

Surendran K, Simon TC. CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. American Journal of Physiol. Renal Physiol. 2003 Apr;284(4):F653-F662.

Surendran K, McCaul SP, Simon TC. A role for Wnt-4 in renal fibrosis. American Journal of Physiol. Renal Physiol. 2002 Mar;282(3):F431-F441.


Surendran K, Vitiello SP, Pearce DA. Lysosome dysfunction in the pathogenesis of kidney diseases. Pediatr Nephrol. 2013 Nov 12. [Epub ahead of print]

Surendran K and Kopan R. Chromatin mediated mechanisms of epithelial differentiation. J Am Soc Nephrol. 2011 Jul;22(7):1208-12.

Kopan R, Cheng HT, Surendran K. Molecular Insights into Segmentation along the Proximal-Distal Axis of the Nephron, J Am Soc Nephrol. 2007 18(7):2014-20.

Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA. BMP-7: a novel treatment for chronic renal and bone disease. Curr Opin Nephrol Hypertens. 2004 Jul;13(4):417-22.

Hruska KA, Saab G, Chaudhary LR, Quinn CO, Lund RJ, and Surendran K. Kidney-bone, bone-kidney, and cell-cell communications in renal osteodystrophy. Semin Nephrol. 2004 Jan;24(1):25-38.


Barak H, Surendran K, Boyle S.

The Role of Notch Signaling in Kidney Development and Disease.  Book chapter in: Notch Signaling in Embryology and Cancer. Edited by: Reichrath J and Reichrath S. Published by Landes Bioscience and Springer (2010).