Jill Weimer, PhD, Lab

Weimer Lab

Primary Research Focus

Dr. Weimer Bio

Research in the Weimer Lab is focused on understanding the processes that control development of the cerebral cortex and how disruption in these processes leads to various neuropediatric diseases. Specifically, the team explores a number of mechanisms involved in neural stem cell proliferation, neuronal polarity, and axonal outgrowth and trafficking with the hope of advancing our knowledge of neurobiology and aiding in the future treatment of rare neural developmental disorders. This includes projects focused on Batten disease, cortical malformations, white matter disorders, neurofibromatosis, and Alzheimer’s disease.
  • Senior Director of Therapeutic Development and Associate Scientist in Children's Health Research Center
  • Associate professor for the Department of Pediatrics at the Sanford School of Medicine at the University of South Dakota
  • Bachelor of Science and doctorate in neuroscience at the University of Rochester, Rochester, NY
  • Postdoctoral fellowship in The Neuroscience Center at the University of North Carolina, Chapel Hill

Sanford Research - Weimer Lab

Behind the research

Dr. Weimer’s research team is interested in understanding mechanisms of polarized signaling involved in development of the cerebral cortex.  These processes are known to regulate the proliferation and placement of neurons, formation of axons in differentiating cells, and long term maintenance and trafficking within these same processes. The Weimer lab draws on expertise in cell and molecular biology, genetics, and behavioral neuroscience to answer questions that bridge from basic mechanisms to translational and clinical approaches to treat human disease.  These questions answer how and why various scaffolding or “signaling complex” form in neurons, how disruption in these complexes can contribute to human disease and determine if these complexes may serve as druggable targets. 

Resources Positions Available
Access Dr. Weimer's publications here. There are zero open positions within the Weimer lab at this time.
Meet members of the Weimer lab here.
Find links and tools here.

 

Lab Projects Contact Information
CRMP2/CLN6/KLC4: Mechanisms that mediate cargo selection and transport in developing & mature axons Telephone: (605) 312-6407
Email: jill.weimer@sanfordhealth.org
MARCKS Associated Signaling Complexes in Cortical Development
Rho GTPase Signaling in the Developing Cerebral Cortex
Multifaced preclinical studies for the treatment of Batten Disease
Neurofibromatosis type 1 Disease Model

 

Weimer Lab in the Press
Sanford Research draws a global team
Dakota Midday: Dr. Jill Weimer On STEM and Young Scientists
Weimer is named the EmBe's 2016 winner of Healthcare and STEM award at the Tribute to Women event
New therapy gives hope in children's fight against fatal Batten disease
Work from the Weimer lab is spotlighted in Good Morning America segment

Groundbreaking Gene Theraoy Clinical Trial Offers Glimmer of Hope for Young Children with Rare Batten Disease

Sanford shares results at Vatican event

Press Archive


 

Lab News

January 2017, Dr. Jill Weimer served on the Translational Research in Pediatrics and Obstetric Pharmacology and Therapeutics grant study section for the National Institutes of Health.

December 2016, Dr. Jill Weimer was an invited speaker at Dordt College in Sioux Center, IA. Dr. Weimer spoke to undergraduate science majors about the strategies used to study rare diseases and training opportunities available at Sanford Research for undergraduate and graduates students.

December 2016, Jon Brudvig, a PhD student in the Weimer lab, recently received a Trainee Research Grant from the University of South Dakota Center for Brain and Behavioral Research (CBBRe) for his project entitled "Novel Roles of MARCKS in Cortical Development and Midline Axon Crossing." CBBRe Research Training Grants provide trainees with funding for their research project as well as experience in writing and reviewing grants.

November 2016, Dr. Weimer was invited to present her work on mechanisms regulating the pathogenesis of CLN6-Batten disease and development of effective therapies to the Department of Pathology at Boston Children's Hospital of Harvard Medical School in Boston, MA.

November 2016, Dr. Weimer organized and presented during a mini-symposium entitled "Building the cerebral cortex: Mechanisms that mediate migration, specification, and axonal outgrowth" as part of the 2016 Society for Neuroscience Meeting in San Diego, CA.

 News Archive