Weimer Lab

Primary Focus

Jill Weimer, PhD

Our primary focus is to understand the mechanisms underlying the mammalian central nervous system development. We hope to gain better understanding of the mechanism required for the polarized spatial restriction, advancing our knowledge of neural stem cell biology and aiding in the future treatment of neural developmental disorders and neurodegenerative diseases.
  • Associate Director and Scientist in the Children's Health Research Center
  • Associate Professor for the Department of Pediatrics at the Sanford School of Medicine, USD
  • BS and PhD in Neuroscience at the University of Rochester
  • Postdoctoral fellowship at the University of North Carolina, Chapel Hill in the Neuroscience Center

Sanford Research - Weimer Lab

Our primary focus is to understand the mechanisms underlying the mammalian central nervous system development. In particular, we are interested in understanding mechanisms of polarized signaling that regulate the proliferation and placement of neuronal progenitors in the developing cerebral cortex and whether similar cellular processes assist in neurons faithful ability to acquire unique yet often complex polarized morphologies.

To approach these questions, we combine mouse genetics, in uterus embryonic manipulation, and ex vivo preparations (e.g. hippocampal dissociated neuronal culture, organotypic brain slice culture) with various assays including two-photon/confocal laser scanning microscopy imaging. Employing these techniques, we hope to gain better understanding of the mechanism required for the polarized spatial restriction of critical signaling complexes in neural progenitors of the developing cerebral cortex, advancing our knowledge of neural stem cell biology and aiding in the future treatment of neural developmental disorders and neurodegenerative diseases.

Resources Lab Projects
Weimer Publications CRMP2: A key regulatory mediator of neuropsychiatric disorders
Lab Members MARCKS-associated signaling complexes in cortical development
Links and Tools Rho GTPase Signaling in the Developing Cerebral Cortex
Positions Available  

 

Press Releases Contact Information
Sanford Research's Weimer Secures NIH Grant Telephone: (605) 312-6407
Sanford Doctor Discusses Brain Development Email: Jill.Weimer@sanfordhealth.org
No Vacation Nation  
Sioux Falls Business Journal, Movers and Shakers  
Weimer lab’s work with a family whose children were recently diagnosed with Batten (Cln6) disease highlighted in CNN and Good housekeeping

Weimer, co-organizer of the annual It’s All About Science Festival held at Sanford Research, speaks on the value of STEM education

 

Lab News
June 6-9th: Jill attended the Children’s Tumor Foundation’s annual research conference in Monterey CA
June 1st: The Weimer team has been joined by 5 new summer interns (Keegan Mechels, Ryan Patrick, Caeden Tinklenberg, Brittany Kuhl, and Darren DeNeui)
May 18-19th: Jill presented at the first annual Sanford Consortium/Sanford Research Stem Cell Symposium at University of California – San Diego
May 5th: Jill presented at the Second Annual Center for Pediatric Research (NIH CoBRE Program) Symposium held at Sanford Research
August 2014: Weimer lab member Ryan O’Toole departed the lab to start on his next adventure as a graduate student at Dartmouth University