Weimer Lab

Sanford Research - Weimer Lab

Our primary focus is to understand the mechanisms underlying the mammalian central nervous system development. In particular, we are interested in understanding mechanisms of polarized signaling that regulate the proliferation and placement of neuronal progenitors in the developing cerebral cortex and whether similar cellular processes assist in neurons faithful ability to acquire unique yet often complex polarized morphologies.

To approach these questions, we combine mouse genetics, in uterus embryonic manipulation, and ex vivo preparations (e.g. hippocampal dissociated neuronal culture, organotypic brain slice culture) with various assays including two-photon/confocal laser scanning microscopy imaging. Employing these techniques, we hope to gain better understanding of the mechanism required for the polarized spatial restriction of critical signaling complexes in neural progenitors of the developing cerebral cortex, advancing our knowledge of neural stem cell biology and aiding in the future treatment of neural developmental disorders and neurodegenerative diseases.

Current lab projects:

I. CRMP2: A key regulatory mediator of neuropsychiatric disorders
II. MARCKS-associated signaling complexes in cortical development
III. Rho GTPase Signaling in the Developing Cerebral Cortex

Press Releases

Sanford Research's Weimer Secures NIH Grant
Sanford Doctor Discusses Brain Development
No Vacation Nation
Sioux Falls Business Journal, Movers and Shakers

Contact Information for Weimer Lab:

Jill Weimer, PhD
Associate Scientist, Sanford Children’s Health Research Center
Sanford Research

Assistant Professor, Department of Pediatrics
Sanford School of Medicine of the University of South Dakota

Sanford Research Center, Room 2240
2301 E 60th Street N
Sioux Falls, SD 57104

Telephone: 605-312-6407
Fax: 605-328-0401

Email: Jill.Weimer@sanfordhealth.org