Jill Weimer Lab

Primary research focus

Jill Weimer, PhD

Research in the Weimer Lab is focused on understanding the mechanisms underlying the mammalian central nervous system development. Dr. Weimer and the team hope to gain a better understanding of the mechanism required for the polarized spatial restriction, advancing our knowledge of neural stem cell biology and aiding in the future treatment of neural developmental disorders and neurodegenerative diseases.
  • Associate director and scientist in the Children's Health Research Center
  • Associate professor for the Department of Pediatrics at the Sanford School of Medicine at the University of South Dakota
  • Bachelor of Science and doctorate in neuroscience at the University of Rochester, Rochester, NY
  • Postdoctoral fellowship in The Neuroscience Center at the University of North Carolina, Chapel Hill

Sanford Research - Weimer Lab

Behind the research

Dr. Weimer’s research team is interested in understanding mechanisms of polarized signaling that regulate the proliferation and placement of neuronal progenitors in the developing cerebral cortex and whether similar cellular processes assist in neurons faithful ability to acquire unique yet often complex polarized morphologies.

To approach these questions, we combine mouse genetics, in uterus embryonic manipulation and ex vivo preparations (e.g. hippocampal dissociated neuronal culture, organotypic brain slice culture) with various assays including two-photon/confocal laser scanning microscopy imaging. Employing these techniques, we hope to gain better understanding of the mechanism required for the polarized spatial restriction of critical signaling complexes in neural progenitors of the developing cerebral cortex, advancing our knowledge of neural stem cell biology and aiding in the future treatment of neural developmental disorders and neurodegenerative diseases.

Resources Positions Available
Access Dr. Weimer's publications here. There are zero open positions within the Weimer lab at this time.
Meet members of the Weimer lab here.
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Lab Projects Contact Information
CRMP2: A key regulatory mediator of neuropsychiatric disorders Telephone: (605) 312-6407
Email: jill.weimer@sanfordhealth.org
MARCKS-associated signaling complexes in cortical develop
Rho GTPase Signaling in the Developing Cerebral Cortex

 

Weimer Lab in the Press
Sanfordhealth.org: Weimer to lead collaborative team in development of novel animal model of neurofibromatosis
KELOLAND.com: Weimer to lead collaborative team in development of novel animal model of neurofibromatosis
Argus Leader: Weimer to lead collaborative team in development of novel animal model of neurofibromatosis
Weimer recognized as a Sioux Falls Mover and Shaker
Dr. Jill Weimer appears on an episode of the national televised program “The Doctors” to discuss her work on Batten disease and with The Charlotte and Gwenyth Gray Foundation
Weimer team secures nearly $440,000 in funding to support Batten disease research
Dr. Jill Weimer appears on local TV program to discuss ongoing Batten’s research
Sanford Research's Weimer Secures NIH Grant
Press Archive

 

Lab News

November 2015, Dr. Jill Weimer gave two invited seminars on her CLN6-Batten disease research. The first was in the Department of Pharmacology at the University of Arizona in Tucson. The second was at the Barrow Neurological Institute at Arizona State University in Phoenix.

November 2015, Dr. Jill Weimer and a USD BBS graduate student with her team, Jon Brudvig, recently published a review article entitled “X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease” in the journal Frontiers in Cellular Neuroscience.

November 2015, Dr. Jill Weimer presented updates on her Batten disease research at Young Harris College in Georgia.

October 2015, Dr. Jill Weimer was recently interviewed for an episode of The Doctors TV show regarding her work on Batten disease in partnership with the Charlotte and Gwenyth Gray Foundation. This taped episode aired October 12th.

October 2015, Jon Brudvig, a BBS PhD student in the Weimer lab, has received a travel award from the Center for Brain Behavior Research to attend the Society for Neuroscience meeting in Chicago to present his research and to attend a stem cell training course.

October 2015, Dr. Jill Weimer received a research grant for nearly $440,000 from The Charlotte and Gwenyth Gray Foundation for her research on finding a cure or treatment for a rare variant form of Batten disease. http://www.sanfordhealth.org/newsroom/2015/10/Sanford-scientist-lands-grant-to-support-Batten-disease-research

 News Archive