H. Eugene Hoyme, MD

My research focuses on the delineation of mechanisms of birth defects and malformation syndromes, specifically on the adverse effects of alcohol on the developing embryo and fetus (fetal alcohol spectrum disorders or FASD).

Accurate and Early Clinical Diagnosis of Fetal Alcohol Spectrum Disorders

The adverse effects of alcohol on the developing fetus represent a continuum of disability.  In 1997, the Institute of Medicine suggested four diagnostic categories within this spectrum.  My primary research focus is on the development and refinement of accurate and timely diagnostic tools for clinicians who evaluate children prenatally exposed to alcohol.  This work is collaborative in nature.  I am part of the Dysmorphology Core of CIFASD (the NIAAA supported international Collaborative Initiative on Fetal Alcohol Spectrum Disorders).  Our work has led to clarification of the IOM diagnostic categories; current projects include development of diagnostic guidelines for FASD in early infancy.

FASD Epidemiology Research

I am part of a multi-site NIAAA funded consortium of institutions conducting international studies of the prevalence of FASD in school age children.  Sanford Research is presently collaborating with the University of New Mexico and the University of North Carolina in studies assessing the prevalence of FASD in Sioux Falls, SD, Great Falls, MT, and Greensboro, NC.


H. Eugene Hoyme, MD
Chief of Genetics and Genomic Medicine, Sanford Health 
Chief Academic Officer, Sanford Health
Senior Scientist, Sanford Research
Professor of Pediatrics, Sanford School of Medicine of the University of South Dakota