Cellular Therapies and Stem Cell Biology

Stem Cells play a critical role in the maintenance of normal human health and in response to diseases. The therapeutic use of stem cells has been used for decades in bone marrow transplants to treat diseases like leukemia and sickle cell anemia. Tissue derived adult stem cells such as mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have emerged as a promising therapeutic for tissue repair and regeneration. Mesenchymal stem cells can be isolated from nearly any type of tissue, are easy to culture and expand, and pre-clinical studies support their safety. Induced pluripotent stem cells can give rise to virtually any cell type in the body and have potential to replace damaged tissues or even model human diseases in the lab.

The Cellular Therapies and Stem Cell Biology Group at Sanford Research is focused on the use of stem cells to investigate and develop novel approaches to treat a number of diseases and conditions. Researchers are using stem cells to understand the cellular mechanisms causing genetic rare diseases and cancers. By knowing the underlying cause of disease, we can better identify potential pathways and targets for patient therapy. The regeneration and repair of tissue from cellular therapies is being studied as a potential therapy for orthopedic conditions, neurodegenerative diseases and traumatic brain injuries. The future of medicine is here. We are bringing the next generation of treatments and cures, and helping you understand what it means for you and your health.

A strong regenerative medicine clinical research program has been established with the first FDA-approved trial for use of adipose derived stem cells as treatment for a partial rotator cuff tear. Continued work and research will undoubtedly lead to new cellular therapy trials in order to legitimize the use of stem cells.

Primary Faculty