Center for Pediatric Research (NIH COBRE)

 Center for Pediatric Research (NIH COBRE)




Center Leadership

The Center for Pediatric Research’s goal is to provide a framework for scientists performing research related to understanding the basic biology of human development in either a unique disease-based model or as it relates to the manifestation of clinical abnormalities that present during childhood. Our interdisciplinary Center applies genetic, biochemical, cell, and molecular biology approaches across model organisms to characterize alterations during development as they pertain to pediatric diseases.

A primary emphasis of the Center is to support and mentor junior investigators (Project Leaders) researching how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. The leadership team provides Project Leaders with an individualized mentorship plan to enhance their professional skills and further their research goals to become successful, independent investigators. Furthermore, the Center supports interdisciplinary cores including Biochemistry, Functional Genomics and Bioinformatics, and Imaging to provide Center affiliates and regional scientists with key expertise and access to the latest technology.

Through our activities, the Center for Pediatric Research fosters a collaborative and supportive environment for its innovative pediatric research laboratories, and contributes to enhance children’s health research in South Dakota and across the upper Midwest.


Sanford Research - Kurt Griffin  

David Pearce, PhD
Principal Investigator

Sanford Project - Zhiguang Guo Kyle Roux, PhD
Program Coordinator

External Advisory Committee




Center Graduates

Jill Weimer, PhD
Rho GTPase Signaling in the Developing Cerebral Cortex  

Lance Lee, PhD
Ciliary Central Pair Proteins in Primary Ciliary Dyskinesia

Peter Vitiello, PhD
Thioredoxin Signaling During Pulmonary Development and Perinatal Oxidative Injury


Protein Biochemistry Core
Core Lead: Kyle Roux, PhD

Molecular Biology Core
Core Lead: Kamesh Surendran, PhD

Imaging Core
Core Leads: Jill Weimer, PhD & Indra Chandrasekar, PhD

Project leaders and other faculty at Sanford Research also have regular access to the Molecular Pathology Core and the Flow Cytometry Core which are funded by COBRE grant 5P20GM103548 (Center for Cancer Biology Research).