The Institutional Biosafety Committee reviews registrations for Recombinant DNA, Pathogens, Infectious Agents, Biological Toxins, and Human Gene Therapy/Pathogen Clinical Trials as mandated by the National Institutes of Health and/or Sanford Research/USD Standard Operating Policies (SOPs). The full IBC meets monthly for discussion and voting on policies and BioRaft Reports.

Each investigator is responsible for registering research materials and describing the protocols in which they will be used in their lab’s BioRaft report. This rule applies to all independent investigators. Collaborators may not "piggy-back" on each others' registrations. Postdoctoral fellows, graduate students, undergraduate/summer interns and research associates are covered by the registrations of their Principal Investigator. The Principal Investigator is ultimately responsible for the registration, training, and safe handling of research materials handled by their personnel.