Lab News

May 2018 Indra Chandrasekar attended the Experimental Biology meeting in San Diego, CA and presented a poster on her lab's research work titled "Novel role(s) for Nonmuscle Myosin 2 isoforms Myh9 and Myh10 in renal epithelial cells and tubular disease. Karla Otterpohl and Ryan Hart were authors from the Chandrasekar Lab. Claire Evans from the Molecular Pathology Core and Kamesh Surendran were also co-authors.

May 2018 Indra Chandrasekar presented an invited seminar titled "New frontiers in cytoskeletal biology: Exploring the role of Nonmuscle Myosin II in renal epithelial transport and kidney disease using novel mouse models and microscopy methods" to the Department of Pharmaceutical Sciences at South Dakota State University.

January 2018 Dr. Indra Chandrasekar published a manuscript in Physiological Reports highlighting the expression and localization pattern of nonmuscle myosin 2 isoforms in the renal epithelial cells of murine kidney. “Nonmuscle myosin 2 proteins encoded by Myh9, Myh10 and Myh14 are uniquely distributed in the tubular segments of murine kidney” 

December 2017 The Chandrasekar lab attended the annual meeting of the American Society for Cell Biology and European Molecular Biology Organization (ASCB-EMBO) in Philadelphia, PA.  Ryan Hart presented a poster titled "Development and implementation of a Förster Resonance Energy Transfer based biosensor for measuring intracellular tension and force”. The poster abstract was selected for an Oral presentation at the Microsymposium. Dr. Chandrasekar presented the talk titled “Novel approaches for studying the cytoskeleton”. 

December 2017 Postdoctoral fellow, Dr. Karla Otterpohl, received an ASCB-Minority Affairs Committee Travel Award to attend the annual meeting of the American Society for Cell Biology and European Molecular Biology.  Dr. Otterpohl presented her posted titled, "Nonmuscle Myosin2 isoforms are uniquely expressed in mouse renal epithelial cells and play a critical role in renal tubular function in adult mice".

September 2017 Drs. Indra Chandrasekar and Lance Lee represented Sanford Research at the recent SD EPSCoR Undergraduate Research Symposium. Dr. Chandrasekar’s research program is part of the multi-institute collaborative supported by SD EPSCoR.

June 2017 Dr. Indra Chandraskear along with a group of basic and clinical scientists and physicians co-authored a research article published in the American Journal of Human Genetics describing a neurological disorder with epilepsy caused by mutations in FRRS1L. Drs. Angela Myers and Tricia Crotwell contributed to the study titled "Loss-of-function mutations in FRRS1L lead to an epileptic-dyskinetic encephalopathy."

February 2017, Indra Chandraskear, PhD, presented her laboratory's research findings on genetic causes of kidney disease during Pediatric Ground Rounds at the USD Sanford School of Medicine. The title of her presentation was "Establishing the role of MYH genes in end stage renal disease".

January 2017, Dr. Indra Chandrasekar gave an invited research seminar to the Department of Biomedical Engineering at the University of South Dakota. The title of her seminar was "Nonmuscle MII takes the center stage in mammalian endocytosis"

December 2016, Dr. Chandrasekar and Dr. Karla Otterpohl attended the Annual meeting of American Society for Cell Biology in San Francisco. They presented a poster entitled "Nonmuscle Myosin II regulates membrane dynamics of endocytic proteins and receptor ligand couple during clathrin mediated endocytosis in epithelial cells. Co-authors on the poster from the Chandrasekar lab include Ryan Hart and Steven Ortmeier.

November 2016,Dr. Chandrasekar was awarded a grant from SD BioSNTR for her research project entitled "Application of Novel Microscopy techniques and FRET based tension sensor probe measure dynamic changes in cellular tension."

October 2016, The Chandrasekar laboratory presented a poster entitled "Loss of Nonmuscle Myosin II in Postnatal Mouse Renal tubules Results in Chronic Kidney Disease" at the 2016 American Society of Nephrology meeting in Chicago, IL.

June 2016, Dr. Chandrasekar recently travelled to Indiana University School of Medicine in Indianapolis as a part of her recently awarded O'Brien fellowship. During this time she received training in intravital imaging of live mouse kidney and performed experiments on the kidney specific conditional KO mouse models from her lab. Dr. Karla Otterpohl, a postdoctoral fellow in the lab, was also able to attend the training.

June 2016, Dr. Chandrasekar recently attended and presented her research at the Gordon Research Conference on Lysosomes and Endocytosis in Andover, NH. Her research poster, which included Sanford co-authors Karla Otterpohl, Ryan Hart, and Steven Ortmeier, focused on “Coordinated Functions of Nonmuscle Myosin II and Membrane Remodeling Proteins during Receptor Mediated Endocytosis in Renal Epithelium.”

December 2015, Dr. Indra Chandrasekar is a co-author on a recent publication in the journal Molecular Biology of the Cell entitled “Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance.”

October 2015, Dr. Indra Chandrasekar received the O’Brien Fellowship from NIH-George M. O’Brien Center for Advanced Renal Microscopic Analysis at Indiana Center for Biological Microscopy.

October 2015, Phuong Pham, a 2015 NSF-REU scholar in the laboratory of Dr. Chandrakar, presented her Sanford research project at the Council for Undergraduate Research’s Research Experiences for Undergraduates 2015 Symposium in Arlington, VA. The title of her presentation, coauthored by Sanford’s Steve Ortmeier and Dr. Chandrakar, was “Coordinated Functions of Nonmuscle Myosin II and Membrane Remodeling Proteins in Clathrin-Mediated Endocytosis.”