Baack Lab

 Baack Lab

Primary Focus

Michelle Baack

Michelle Baack’s research is focused on establishing the under-recognized role of lipid disturbances in the developmental programming of disease. Disease starts long before any symptoms ever develop and is often triggered by genetic and environmental influences.

Although genes are encoded at conception, the environment can alter how genes are expressed (turned off or on). When an environmental stimulus occurs during a critical window of early development to cause life-long changes in the structure and function of the body, this is called developmental programming.

To help improve the long term outcomes of high-risk babies, Dr. Baack’s lab studies how maternal and neonatal nutrition, specifically various types of fats, can increase or decrease the risk of disease, such as obesity, diabetes, dyslipidemia, hypertension, cardiovascular and neurologic consequences.


  • Michelle BaackAssociate scientist in developmental biology
  • Assistant professor, Department of Pediatrics, Neonatal-Perinatal Medicine, Sanford School of Medicine of the University of South Dakota
  • Bachelor of Science in pharmacy from South Dakota State University, Brookings, SD
  • Doctor of Medicine from the University of South Dakota-School of Medicine, Sioux Falls, SD
  • Pediatric residency training from the University of Nebraska Medical Center-Creighton Joint Pediatric Residency Program, Omaha, NE
  • Fellowship in neonatal and perinatal medicine at the University of Iowa, Iowa City, IA
Baack Lab Baack Lab

Behind the research

To meet this objective, the Baack lab research has both a clinical and basic science platforms. Our clinical trials have focused on protecting babies who are born too early. The premature infant is born deficient in omega-3 fatty acids, which are essential for normal health, brain and retinal development. A clinical trial in the Boekelheide NICU focuses on developing new ways to overcome this deficiency with the goal to prevent significant complications of prematurity.

Additionally, Dr. Baack and the research team are working to educate mothers about the importance of a normal intake of omega-3 fats like docosahexaenoic acid (DHA) during breastfeeding. Through the Mother’s Milk DHA study, moms can learn how to assure the breast milk they give their baby is a good source of DHA.

In contrast, Dr. Baack’s basic science research focuses on decreasing fetal exposure to excess “bad” fats (saturated and mono-unsaturated fats) in order to prevent cardiovascular disease even before it begins. Infants born to mothers with diabetes or obesity during the pregnancy are at higher risk of cardiac disease later in life.

Dr. Baack’s lab created a rat model to study how this occurs. We discovered that a diet high in saturated fat, especially alongside diabetic pregnancy, causes excess fat deposition in the developing heart. Moreover, lipid deposition during early development is associated with enlargement of the cardiomyocytes, poor heart function and developmental programming of fuel metabolism, which may increase the risk of heart disease throughout a lifetime.

Dr. Baack and the team are also using this same rat model in collaboration with other labs to understand how maternal diabetes or dyslipidemia may cause abnormal brain, kidney, pancreas and lung vessel development. They hope to raise awareness about the importance of good nutrition and how to balance both “good” and “bad” fats during high-risk pregnancy and early infant development.


Access Dr. Baack's publications here.  
Meet members of the Baack lab here.  
Contact Us News
Phone: (605) 312-6420  View news about Baack lab here.
Fax: (605) 312-6071  


Lab News

June 2016, Dr. Michelle Baack attended and presented at the 76th Scientific Session of the American Diabetes Association meeting in New Orleans, LA. Her talk was entitled “Maternal High-fat Diet Exacerbates Developmentally Programmed Cardiovascular Disease in Offspring of Diabetic Pregnancies through Impaired Cardiac Metabolism” as part of the Unraveling the Mysteries of Teratogenesis, Fetal Programming, and Adverse Pregnancy Outcomes Using Pioneering Technologies Session.

June 2016, Dr. Michelle Baack recently attended the NIDDK/NHLBI Mitochondrial Biology Symposium: Novel Roles of Mitochondrial in Health and Disease, Bethesda, MD. She presented on her research focused on “The Role of Bioenergetics and Mitochondrial Function in Developmentally Programmed Cardiac Disease in Offspring of Diabetic Pregnancy.”

May 2016, Dr. Michelle Baack recently attended the Pediatric Academic Society Meeting in Baltimore, MD. While there, she was inducted into the Society for Pediatric Research.  Additionally, she gave two poster presentations and a platform presentations on her work exploring how “Maternal Tobacco Smoke Exposure Impairs Placental Function and Induces Sex-Specific Alterations in Fetal Fatty Acids.” 

May 2016, Dr. Michelle Baack recently met in Pierre as part of a Governor’s Appointed Medicaid Advisory Committee.  Dr. Baack has served on this MAC since March 2014 and was appointed by Governor Daugaard.  The MAC – Medicaid Advisory Committee assists and advises the Department of Social Services in serving SD Medicaid recipients.  This month discussed Home and Community Based Services, Genetic Testing and Counseling, Budget, Applied Behavioral Services and expansion of Autism treatment and hear an update about Medicaid Expansion in our state. 

March 2016, Dr. Michelle Baack’s recent publication entitled “Maternal high-fat diet impairs cardiac function in offspring of diabetic pregnancy through metabolic stress and mitochondrial dysfunction” in the journal American Journal of Physiology - Heart and Circulatory Physiology has been nominated for distinction in scholarship for APS select  This is a collection of articles from the APS journals that showcases some of the best recently published articles in physiological research.

 News Archive