Pearce Lab

Pearce Lab for Genetically Inherited Diseases of Children

The Pearce lab has a general interest in genetically inherited diseases of children. More specifically our goal is to contribute to the understanding of the molecular basis of several pediatric neurodegenerative diseases.
 

Batten Disease

The disease that is our primary focus is Batten disease. Batten disease is a type of Neuronal Ceroid Lipofuscinosis, so called because of the fact that a part of the cell called the lysosome accumulates a heterogeneous mix of fat-like material called lipofuscin. Many other diseases that result in brain degenerative diseases in children result from accumulation of other biological compounds in the lysosome. These are collectively termed Lysosomal Storage Disorders. Through exploration of our website you will find that we are interested in these other Lysosomal Storage Disorders also, but resources and ideas currently limit us to focus most of our efforts on Batten disease.

Additional Information on Pearce Lab Research

Lecture on JNCL Research by Dr. David Pearce

Donate to Batten Research


Contact Information for Pearce Lab:

David A. Pearce
President of Research, Sanford Health
Senior Scientist, Children’s Health Research Center
Professor, Department of Pediatrics, Sanford School of Medicine of the University of South Dakota

2301 E 60th Street North | Sioux Falls, SD 57104

PHONE: 605-312-6004
FAX: 605-328-0401
David.Pearce@sanfordhealth.org

 

Lab News

December 2015, The Pearce team, including Dr. David Pearce, Dr. Attila Kovacs, and Jake Miller co-authored an article in the Journal of Cellular and Molecular Medicine entitled: “Tissue-specific variation in nonsense mutant transcript level and drug-induced read-through efficiency in the Cln1R151X mouse model of INCL.”

December 2015, The Pearce team, including Drs. David Pearce, Chun Chan, and Attila Kovacs as well as MD/PhD candidates Sam Hersrud and Ryan Geraets recently published an article entitled “Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis” in the journal FEBS.

October 2015, Drs. Attila Kovacs and David Pearce coauthored a manuscript entitled “Abnormally increased surface expression of AMPA receptors in the cerebellum, cortex and striatum of Cln3-/- mice” published in Neuroscience Letters.